| Full protein name | RNA-binding protein FUS;75 kDa DNA-pairing protein;Oncogene FUS;Oncogene TLS;POMp75;Translocated in liposarcoma protein |
| Gene name | FUS;TLS |
| Species | Homo sapiens |
| Localization | Nucleus. |
| Description | FUS (RNA-binding protein FUS), an essential paraspeckle component, has 27 repeats of Y[G/S]QQ or [S/G]Y[S/G] and contains a N terminal PLD and a RRM domain, two RGG-rich domains separated by a zinc finger (ZnF), and a non-canonical PY nuclear localization signal (NLS). The LC domains, includes the N-terminal SYGQ-rich domain and C-terminal three RGG domains enriched in RGG/RG motifs that are extensively modified with asymmetric dimethyl groups by PRMT1 or PRMT8. The PLDs of FUS family proteins are intrinsically disordered and have low complexity. The PLDs are typically enriched in tyrosine. The RBDs comprise one or more folded RNA recognition modules (RNA recognition motif, RRM), but they also carry regions of significant intrinsic disorder. The intrinsically disordered regions in RBDs are typically enriched in glycine and positively charged residues, such as arginine. FUS forms liquid compartments at sites of DNA damage and in the cytoplasm upon stress. It is enriched in the nucleus and involved in transcription, DNA repair, and RNA biogenesis. |
| GO term | GO:0003682; chromatin binding; IDA:UniProtKB. GO:0003677; DNA binding; IEA:UniProtKB-KW. GO:0030331; estrogen receptor binding; IEA:Ensembl. GO:0042802; identical protein binding; IPI:IntAct. GO:0035255; ionotropic glutamate receptor binding; IEA:Ensembl. GO:0046872; metal ion binding; IEA:UniProtKB-KW. GO:0003730; mRNA 3'-UTR binding; IEA:Ensembl. GO:0031489; myosin V binding; IEA:Ensembl. GO:0046965; retinoid X receptor binding; IEA:Ensembl. GO:0003723; RNA binding; IDA:MGI. GO:0046966; thyroid hormone receptor binding; IEA:Ensembl. GO:0003713; transcription coactivator activity; IDA:CACAO. GO:0003712; transcription coregulator activity; IBA:GO_Central. |
| Full sequence length | 526 |
| Database linked | MobiDB :P35637 DisProt :DP01102 FuzDB :FC00097 IDEAL :IID00451 OMIM :137070 |
| IDR Region | 1 526 |
| LCR Region | 1 526 |