| Full protein name | Probable ATP-dependent RNA helicase DDX4;DEAD box protein 4;Vasa homolog |
| Gene name | DDX4;VASA |
| Species | Homo sapiens |
| Localization | Cytoplasm; Cytoplasm, perinuclear region. |
| Description | ATP-dependent RNA helicase required during spermatogenesis. Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Ddx4 proteins are essential for the assembly and maintenance of the related nuage in mammals, P-granules in worms, and pole plasm and polar granules in flies. In addition to a central DEAD-box RNA helicase domain that uses ATP to unwind short RNA duplexes. Ddx4 has extended N and C termini that are predicted to be intrinsically disordered. The Ddx4 N-terminal intrinsically disordered region maintains transient tertiary contacts that keep the protein compact. |
| GO term | GO:0005524; ATP binding; IEA:UniProtKB-KW. GO:0140603; ATP hydrolysis activity; ISS:UniProtKB. GO:0003723; RNA binding; IBA:GO_Central. GO:0003724; RNA helicase activity; IBA:GO_Central. |
| Full sequence length | 724 |
| Database linked | MobiDB :Q9NQI0 DisProt :DP01065 OMIM :605281 |
| IDR Region | 1 724 |
| LCR Region | 1 724 |