| Full protein name | Small ubiquitin-related modifier 3;SUMO-3;SMT3 homolog 1;SUMO-2;Ubiquitin-like protein SMT3A;Smt3A;SUMO3;SMT3A;SMT3H1 |
| Gene name | SUMO3 |
| Species | Homo sapiens |
| Localization | Nucleus; PML body; Cytoplasm. |
| Description | Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. Plays a role in the regulation of sumoylation status of SETX. |
| GO term | GO:0031386; protein tag; IBA:GO_Central. GO:0044389; ubiquitin-like protein ligase binding; IBA:GO_Central. |
| Full sequence length | 103 |
| Database linked | MobiDB :P55854 FuzDB :FC00123 |
| IDR Region | 1 103 |
| LCR Region | 1 103 |