| Full protein name | E3 SUMO-protein ligase PIAS2;Androgen receptor-interacting protein 3;DAB2-interacting protein;E3 SUMO-protein transferase PIAS2;Msx-interacting zinc finger protein;PIAS-NY protein;Protein inhibitor of activated STAT x;Protein inhibitor of activated STAT2 |
| Gene name | PIAS2;PIASX |
| Species | Homo sapiens |
| Localization | Nucleus speckle; Nucleus, PML body; Nucleus. |
| Description | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. |
| GO term | GO:0003677; DNA binding; IEA:UniProtKB-KW. GO:0061629; RNA polymerase II-specific DNA-binding transcription factor binding; IBA:GO_Central. GO:0061665; SUMO ligase activity; IDA:ParkinsonsUK-UCL. GO:0019789; SUMO transferase activity; EXP:Reactome. GO:0003712; transcription coregulator activity; IBA:GO_Central. GO:0008134; transcription factor binding; IPI:ParkinsonsUK-UCL. GO:0031625; ubiquitin protein ligase binding; IEA:Ensembl. GO:0008270; zinc ion binding; TAS:ProtInc. |
| Full sequence length | 621 |
| Database linked | MobiDB :O75928 DisProt :DP01675 FuzDB :FC00128 IDEAL :IID00136 OMIM :603567 |
| IDR Region | 1 621 |
| LCR Region | 1 621 |