| Full protein name | Tyrosine-protein kinase ABL1;Abelson murine leukemia viral oncogene homolog 1;Abelson tyrosine-protein kinase 1;Proto-oncogene c-Abl;p150 |
| Gene name | ABL1;ABL;JTK7 |
| Species | Homo sapiens |
| Localization | Cytoplasm, cytoskeleton; Nucleus; Mitochondrion. |
| Description | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. |
| GO term | GO:0051015; actin filament binding; IEA:Ensembl. GO:0003785; actin monomer binding; TAS:UniProtKB. GO:0005524; ATP binding; IDA:UniProtKB. GO:0000405; bubble DNA binding; IDA:ARUK-UCL. GO:0003677; DNA binding; NAS:UniProtKB. GO:0046875; ephrin receptor binding; ISS:ARUK-UCL. GO:0000400; four-way junction DNA binding; IDA:ARUK-UCL. GO:0016301; kinase activity; IMP:UniProtKB. GO:0000287; magnesium ion binding; IDA:UniProtKB. GO:0030145; manganese ion binding; IDA:UniProtKB. GO:0051019; mitogen-activated protein kinase binding; IPI:BHF-UCL. GO:0038191; neuropilin binding; IPI:BHF-UCL. GO:0004515; nicotinate-nucleotide adenylyltransferase activity; TAS:UniProtKB. GO:0004715; non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB. GO:0001784; phosphotyrosine residue binding; IPI:CAFA. GO:0070064; proline-rich region binding; IDA:UniProtKB. GO:0008022; protein C-terminus binding; IPI:UniProtKB. GO:0004672; protein kinase activity; IDA:MGI. GO:0005080; protein kinase C binding; IPI:ParkinsonsUK-UCL. GO:0004713; protein tyrosine kinase activity; IDA:UniProtKB. GO:1990837; sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. GO:0042169; SH2 domain binding; IPI:CAFA. GO:0017124; SH3 domain binding; IPI:UniProtKB. GO:0019905; syntaxin binding; IPI:UniProtKB. GO:0003713; transcription coactivator activity; TAS:ARUK-UCL. GO:0004714; transmembrane receptor protein tyrosine kinase activity; IEA:RHEA. |
| Full sequence length | 1130 |
| Database linked | MobiDB :P00519 OMIM :189980 |
| IDR Region | 1 1130 |
| LCR Region | 1 1130 |