| Full protein name | Nucleophosmin;Nucleolar phosphoprotein B23;Nucleolar protein NO38;Numatrin |
| Gene name | NPM1;NPM |
| Species | Homo sapiens |
| Localization | Nucleus, nucleolus; Nucleus, nucleoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. |
| Description | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. NPM1 contains an N-terminal oligomerization domain (OD) which has been shown to be necessary to form an ordered pentameric structure, a central disordered domain containing acidic tracts (A2/A3), and a C-terminal RNA binding domain (RRM). The OD of NPM1 can form a pentamer to generate multivalency and could potentially increase the affinity of its RRM domain for rRNA. NPM1 is a multivalent protein containing three acidic LCD tracts permitting interaction with many nucleolar binding partners with multivalent arginine-rich motifs (R-motifs). |
| GO term | GO:0003682; chromatin binding; IBA:GO_Central. GO:0001046; core promoter sequence-specific DNA binding; IDA:CAFA. GO:0140297; DNA-binding transcription factor binding; IPI:CAFA. GO:0042393; histone binding; IDA:UniProtKB. GO:0051059; NF-kappaB binding; IDA:UniProtKB. GO:0042803; protein homodimerization activity; IDA:UniProtKB. GO:0019901; protein kinase binding; IPI:UniProtKB. GO:0004860; protein kinase inhibitor activity; IDA:UniProtKB. GO:0047485; protein N-terminus binding; IEA:Ensembl. GO:0043023; ribosomal large subunit binding; IDA:MGI. GO:0043024; ribosomal small subunit binding; IDA:MGI. GO:0003723; RNA binding; IDA:UniProtKB. GO:0019843; rRNA binding; IEA:Ensembl. GO:0030957; Tat protein binding; IDA:UniProtKB. GO:0003713; transcription coactivator activity; IDA:UniProtKB. GO:0051082; unfolded protein binding; IDA:UniProtKB. |
| Full sequence length | 294 |
| Database linked | MobiDB :P06748 DisProt :DP01474 AmyPro :AP00049 FuzDB :FC00070 IDEAL :IID00295 OMIM :164040 |
| IDR Region | 1 294 |
| LCR Region | 1 294 |