| Full protein name | Synaptic functional regulator FMR1;Fragile X mental retardation protein 1 |
| Gene name | FMR1 |
| Species | Homo sapiens |
| Localization | Nucleus; Nucleus, nucleolus; Chromosome, centromere; Chromosome; Cytoplasm; Cytoplasm, perinuclear region; Cytoplasm, Cytoplasmic ribonucleoprotein granule; Perikaryon; Cell projection; Cell projection, axon; Cell projection, dendrite; Cell projection, dendritic spine; Cell junction, synapse, synaptosome; Cell projection, growth cone; Cell projection, synapse; Cell junction, synapse, postsynaptic cell membrane; Cell junction, synapse, presynaptic cell membrane; Cell membrane; Cytoplasm, Stress granule. |
| Description | Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Contains RGGs rich domains. |
| GO term | GO:0003682; chromatin binding; ISS:UniProtKB. GO:0070840; dynein complex binding; ISS:UniProtKB. GO:0002151; G-quadruplex RNA binding; IDA:UniProtKB. GO:0042802; identical protein binding; IDA:UniProtKB. GO:0035064; methylated histone binding; IDA:UniProtKB. GO:0008017; microtubule binding; ISS:UniProtKB. GO:0035198; miRNA binding; IDA:UniProtKB. GO:0003730; mRNA 3'-UTR binding; IDA:UniProtKB. GO:0048027; mRNA 5'-UTR binding; IDA:UniProtKB. GO:0003729; mRNA binding; IDA:UniProtKB. GO:0034046; poly(G) binding; IDA:UniProtKB. GO:0008266; poly(U) RNA binding; IDA:UniProtKB. GO:0046982; protein heterodimerization activity; IDA:UniProtKB. GO:0042803; protein homodimerization activity; IDA:UniProtKB. GO:0043022; ribosome binding; IPI:UniProtKB. GO:0003723; RNA binding; IDA:UniProtKB. GO:0035613; RNA stem-loop binding; IDA:UniProtKB. GO:0033592; RNA strand annealing activity; IDA:UniProtKB. GO:1990825; sequence-specific mRNA binding; IDA:UniProtKB. GO:0035197; siRNA binding; IDA:UniProtKB. GO:0031369; translation initiation factor binding; IPI:UniProtKB. GO:0045182; translation regulator activity; IBA:GO_Central. GO:0030371; translation repressor activity; IDA:UniProtKB. GO:0044325; transmembrane transporter binding; IPI:UniProtKB. |
| Full sequence length | 632 |
| Database linked | MobiDB :Q06787 DisProt :DP00134 FuzDB :FC00153 OMIM :309550 |
| IDR Region | 1 632 |
| LCR Region | 1 632 |