| Full protein name | Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau |
| Gene name | MAPT;MAPTL;MTBT1;TAU |
| Species | Homo sapiens |
| Localization | Cytoplasm, cytosol; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Cytoplasm, cytoskeleton; Cell projection, axon; Cytoplasm; Cell projection, dendrite. |
| Description | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau is one of the first characterized intrinsically disordered proteins and contains up to four binding sites for tubulin. The amino acid sequence of human Tau contains only a small number of hydrophobic residues and is of low complexity. Tau protein contains the N-terminal projection domain(NT-PD), proline-rich domain(PRD), tubulin binding repeats 1 to 4(TB1–TB4), C-terminal projection domain(CT-PD). |
| GO term | GO:0003779; actin binding; TAS:ParkinsonsUK-UCL. GO:0034185; apolipoprotein binding; IPI:BHF-UCL. GO:0051087; chaperone binding; IPI:ARUK-UCL. GO:0003677; DNA binding; ISS:ParkinsonsUK-UCL. GO:0003690; double-stranded DNA binding; TAS:ARUK-UCL. GO:0034452; dynactin binding; TAS:ParkinsonsUK-UCL. GO:0019899; enzyme binding; IPI:UniProtKB. GO:0099077; histone-dependent DNA binding; TAS:ARUK-UCL. GO:0051879; Hsp90 protein binding; IPI:ARUK-UCL. GO:0042802; identical protein binding; IDA:CAFA. GO:0071813; lipoprotein particle binding; IPI:UniProtKB. GO:0008017; microtubule binding; IDA:UniProtKB. GO:0099609; microtubule lateral binding; IMP:CAFA. GO:0003680; minor groove of adenine-thymine-rich DNA binding; TAS:ARUK-UCL. GO:0035091; phosphatidylinositol binding; TAS:ARUK-UCL. GO:1902936; phosphatidylinositol bisphosphate binding; TAS:ARUK-UCL. GO:0019901; protein kinase binding; IPI:ARUK-UCL. GO:0051721; protein phosphatase 2A binding; TAS:ParkinsonsUK-UCL. GO:0030674; protein-macromolecule adaptor activity; TAS:ARUK-UCL. GO:0003723; RNA binding; TAS:ARUK-UCL. GO:0043565; sequence-specific DNA binding; TAS:ARUK-UCL. GO:0017124; SH3 domain binding; IPI:UniProtKB. GO:0003697; single-stranded DNA binding; TAS:ARUK-UCL. |
| Full sequence length | 441 |
| Database linked | MobiDB :P10636 DisProt :DP01100 AmyPro :AP00012 FuzDB :FC00131 OMIM :157140 |
| IDR Region | 1 441 |
| LCR Region | 1 441 |