| Full protein name | Chromobox protein homolog 5;Antigen p25;Heterochromatin protein 1 homolog alpha |
| Gene name | CBX5;HP1A |
| Species | Homo sapiens |
| Localization | Nucleus; Chromosome; Chromosome, centromere. |
| Description | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. The N terminal end, hinge, and C-terminal extension (CTE) regions of HP1α contain sequences with a high propensity for intrinsic disorder. |
| GO term | GO:0140297; DNA-binding transcription factor binding; ISS:BHF-UCL. GO:0042802; identical protein binding; IPI:IntAct. GO:0035064; methylated histone binding; IDA:UniProtKB. GO:0044877; protein-containing complex binding; IDA:UniProtKB. GO:0030674; protein-macromolecule adaptor activity; ISS:BHF-UCL. GO:0043021; ribonucleoprotein complex binding; IDA:UniProtKB. |
| Full sequence length | 191 |
| Database linked | MobiDB :P45973 OMIM :604478 |
| IDR Region | 1 191 |
| LCR Region | 1 191 |