| Full protein name | Growth factor receptor-bound protein 2;Adapter protein GRB2;Protein Ash;SH2/SH3 adapter GRB2 |
| Gene name | GRB2;ASH |
| Species | Homo sapiens |
| Localization | Nucleus; Cytoplasm; Endosome; Golgi apparatus. |
| Description | Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death. Synapsin 1 interacts with several SH3 domain containing proteins via its IDR, Grb2 contains two SH3 domains. |
| GO term | GO:0046875; ephrin receptor binding; IPI:UniProtKB. GO:0005154; epidermal growth factor receptor binding; IPI:UniProtKB. GO:0042802; identical protein binding; IPI:IntAct. GO:0043560; insulin receptor substrate binding; IPI:UniProtKB. GO:0005168; neurotrophin TRKA receptor binding; IPI:UniProtKB. GO:0001784; phosphotyrosine residue binding; IPI:CAFA. GO:0019901; protein kinase binding; IPI:BHF-UCL. GO:0019903; protein phosphatase binding; IEA:Ensembl. GO:0044877; protein-containing complex binding; IEA:Ensembl. GO:0030674; protein-macromolecule adaptor activity; IEA:Ensembl. GO:0003723; RNA binding; HDA:UniProtKB. GO:0017124; SH3 domain binding; IDA:UniProtKB. |
| Full sequence length | 217 |
| Database linked | MobiDB :P62993 DisProt :DP00210 IDEAL :IID00459 OMIM :108355 |
| IDR Region | 1 217 |
| LCR Region | 1 217 |