| Full protein name | Nucleolysin TIA-1;RNA-binding protein TIA-1;T-cell-restricted intracellular antigen-1 |
| Gene name | Tia1;Tia |
| Species | Mus musculus |
| Localization | Cytoplasm, Stress granule; Nucleus. |
| Description | T cell intracellular antigen-1 (TIA-1), a prion-related RNA binding protein. Overexpression of the prion-related domain alone blocks the formation of stress granules in a dominant negative manner, while overexpression of full-length TIA-1 is sufficient to cause the formation of stress granules in the absence of stress. TIA1 is a prominent Stress granule(SG) component and the LCD of TIA1 plays a central role in promoting SG assembly. TIA1 is a prototypical hnRNP that contains three RNA recognition motifs (RRMs) and a C-terminal LCD that is predicted to be intrinsically disordered. Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. |
| GO term | GO:0035925; mRNA 3'-UTR AU-rich region binding; IDA:MGI. |
| Full sequence length | 386 |
| Database linked | MobiDB :P52912 AmyPro :AP00057 |
| IDR Region | 1 386 |
| LCR Region | 1 386 |