| Full protein name | DNA-directed RNA polymerase II subunit RPB1;DNA-directed RNA polymerase II subunit A;DNA-directed RNA polymerase III largest subunit;RNA-directed RNA polymerase II subunit RPB1 |
| Gene name | POLR2A;POLR2 |
| Species | Homo sapiens |
| Localization | Nucleus; Cytoplasm. |
| Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines. The CTD is highly soluble and contains 52 heptapeptide repeats of the consensus sequence YSPTSPS. |
| GO term | GO:0003677; DNA binding; TAS:ProtInc. GO:0003899; DNA-directed 5'-3' RNA polymerase activity; TAS:ProtInc. GO:0019900; kinase binding; IPI:UniProtKB. GO:0046872; metal ion binding; IEA:UniProtKB-KW. GO:1990841; promoter-specific chromatin binding; IDA:UniProtKB. GO:0008022; protein C-terminus binding; IPI:UniProtKB. GO:0003723; RNA binding; HDA:UniProtKB. GO:0003968; RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW. GO:0031625; ubiquitin protein ligase binding; IPI:BHF-UCL. |
| Full sequence length | 1970 |
| Database linked | MobiDB :P24928 DisProt :DP01284 FuzDB :FC00149 IDEAL :IID00126 OMIM :180660 |
| IDR Region | 1 1970 |
| LCR Region | 1 1970 |