| Full protein name | Sequestosome-1;EBI3-associated protein of 60 kDa;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;Ubiquitin-binding protein p62 |
| Gene name | SQSTM1;ORCA;OSIL |
| Species | Homo sapiens |
| Localization | Cytoplasm, cytosol; Late endosome; Lysosome; Cytoplasmic vesicle, autophagosome; Nucleus; Endoplasmic reticulum; Nucleus, PML body; Cytoplasm, myofibril, sarcomere. |
| Description | Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 body, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML body in the nucleus. p62 has an N-terminal PB1 domain and a C-terminal ubiquitin-associated (UBA) domain. p62 is organized into flexible polymers through the PB1 domain and binds to ubiquitin through the UBA domain. p62 is a common component of various cellular inclusion body that are often found in diseases affecting the brain and liver. These cellular inclusion body include Mallory–Denk body, intracytoplasmic hyaline body, and α1 antitrypsin aggregates in the liver; and Lewy body, neurofibrillary tangles, and huntingtin aggregates in the brain. |
| GO term | GO:0019899; enzyme binding; IPI:UniProtKB. GO:0042802; identical protein binding; IPI:IntAct. GO:0035255; ionotropic glutamate receptor binding; ISS:ARUK-UCL. GO:0070530; K63-linked polyubiquitin modification-dependent protein binding; IDA:UniProtKB. GO:0019901; protein kinase binding; IDA:UniProtKB. GO:0005080; protein kinase C binding; IPI:UniProtKB. GO:0004674; protein serine/threonine kinase activity; NAS:UniProtKB. GO:0044877; protein-containing complex binding; IEA:Ensembl. GO:0030971; receptor tyrosine kinase binding; TAS:ProtInc. GO:0042169; SH2 domain binding; IDA:UniProtKB. GO:0043130; ubiquitin binding; IDA:UniProtKB. GO:0031625; ubiquitin protein ligase binding; IDA:UniProtKB. GO:0008270; zinc ion binding; IEA:InterPro. |
| Full sequence length | 440 |
| Database linked | MobiDB :Q13501 DisProt :DP01111 FuzDB :FC00092 IDEAL :IID00383 OMIM :601530 |
| IDR Region | 1 440 |
| LCR Region | 1 440 |