| Full protein name | Microtubule-associated proteins 1A/1B light chain 3B;Autophagy-related protein LC3 B;Autophagy-related ubiquitin-like modifier LC3 B;MAP1 light chain 3-like protein 2;MAP1A/MAP1B light chain 3 B;Microtubule-associated protein 1 light chain 3 beta |
| Gene name | MAP1LC3B;MAP1ALC3 |
| Species | Homo sapiens |
| Localization | Cytoplasm, cytoskeleton; Endomembrane system; Lipid-anchor; Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor; Cytoplasmic vesicle, autophagosome. |
| Description | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. LC3 can directly bind to p62, and the interaction between p62 and LC3 has been proposed as the mechanism for linking p62-containing protein aggregates to the autophagy machinery. |
| GO term | GO:0097001; ceramide binding; IDA:UniProtKB. GO:0008017; microtubule binding; IBA:GO_Central. GO:0031625; ubiquitin protein ligase binding; IPI:UniProtKB. |
| Full sequence length | 125 |
| Database linked | MobiDB :Q9GZQ8 IDEAL :IID00346 OMIM :609604 |
| IDR Region | 1 125 |
| LCR Region | 1 125 |