| Full protein name | Mediator of RNA polymerase II transcription subunit 1;Activator-recruited cofactor 205 kDa component;Mediator complex subunit 1;Peroxisome proliferator-activated receptor-binding protein;Thyroid hormone receptor-associated protein complex 220 kDa component;Thyroid receptor-interacting protein 2;Vitamin D receptor-interacting protein complex component DRIP205;p53 regulatory protein RB18A |
| Gene name | MED1;ARC205;CRSP1;CRSP200;DRIP205;DRIP230;PBP;PPARBP;PPARGBP;RB18A;TRAP220;TRIP2 |
| Species | Homo sapiens |
| Localization | Nucleus. |
| Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells. BRD4 and MED1 contain large intrinsically disordered regions (IDRs), including high proline and glutamine content (BRD4), high serine content (MED1), and acidic and basic regions (BRD4 and MED1). |
| GO term | GO:0003682; chromatin binding; IMP:UniProtKB. GO:0031490; chromatin DNA binding; IEA:Ensembl. GO:0030331; estrogen receptor binding; IPI:UniProtKB. GO:0050693; LBD domain binding; IPI:UniProtKB. GO:0016922; nuclear receptor binding; IDA:UniProtKB. GO:0030374; nuclear receptor coactivator activity; IMP:UniProtKB. GO:0042975; peroxisome proliferator activated receptor binding; IPI:UniProtKB. GO:1990841; promoter-specific chromatin binding; IEA:Ensembl. GO:0044877; protein-containing complex binding; IEA:Ensembl. GO:0042974; retinoic acid receptor binding; IPI:UniProtKB. GO:0000978; RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl. GO:0046966; thyroid hormone receptor binding; IDA:UniProtKB. GO:0003713; transcription coactivator activity; IDA:UniProtKB. GO:0003712; transcription coregulator activity; IDA:UniProtKB. GO:0003714; transcription corepressor activity; ISS:UniProtKB. GO:0008134; transcription factor binding; IPI:UniProtKB. GO:0061630; ubiquitin protein ligase activity; IEA:Ensembl. GO:0042809; vitamin D receptor binding; IPI:UniProtKB. |
| Full sequence length | 1581 |
| Database linked | MobiDB :Q15648 IDEAL :IID00173 OMIM :604311 |
| IDR Region | 1 1581 |
| LCR Region | 1 1581 |