| Full protein name | Tyrosine-protein kinase Fyn;Proto-oncogene Syn;Proto-oncogene c-Fyn;Src-like kinase;p59-Fyn |
| Gene name | FYN |
| Species | Homo sapiens |
| Localization | Cytoplasm; Nucleus; Cell membrane. |
| Description | Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. The RNA-binding protein heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) carries mRNA targets in MLOs called transport granules in neurons and oligodendrocytes. At sites of local translation, hnRNPA2 is phosphorylated by the tyrosine protein kinase Fyn, releasing the mRNA for translation. Fyn recognizes targets through its SH3 domain (Fyn-SH3). |
| GO term | GO:0043014; alpha-tubulin binding; ISS:ARUK-UCL. GO:0005524; ATP binding; IEA:UniProtKB-KW. GO:0042609; CD4 receptor binding; IEA:Ensembl. GO:0042610; CD8 receptor binding; IEA:Ensembl. GO:0097718; disordered domain specific binding; IPI:CAFA. GO:0019899; enzyme binding; IPI:ARUK-UCL. GO:0046875; ephrin receptor binding; IPI:UniProtKB. GO:0070851; growth factor receptor binding; IPI:UniProtKB. GO:0042802; identical protein binding; IPI:IntAct. GO:0046872; metal ion binding; IEA:UniProtKB-KW. GO:0004715; non-membrane spanning protein tyrosine kinase activity; IDA:ARUK-UCL. GO:0051428; peptide hormone receptor binding; IEA:Ensembl. GO:0043548; phosphatidylinositol 3-kinase binding; IEA:Ensembl. GO:0016004; phospholipase activator activity; IDA:ARUK-UCL. GO:0043274; phospholipase binding; IPI:ARUK-UCL. GO:0004713; protein tyrosine kinase activity; IMP:UniProtKB. GO:0097110; scaffold protein binding; IPI:ARUK-UCL. GO:0005102; signaling receptor binding; IBA:GO_Central. GO:0042608; T cell receptor binding; IEA:Ensembl. GO:0048156; tau protein binding; ISS:ARUK-UCL. GO:0050321; tau-protein kinase activity; NAS:ARUK-UCL. GO:0004714; transmembrane receptor protein tyrosine kinase activity; IEA:RHEA. GO:0044325; transmembrane transporter binding; IEA:Ensembl. GO:0031802; type 5 metabotropic glutamate receptor binding; ISS:ARUK-UCL. |
| Full sequence length | 537 |
| Database linked | MobiDB :P06241 FuzDB :FC00122 OMIM :137025 |
| IDR Region | 1 537 |
| LCR Region | 1 537 |