| Full protein name | Death domain-associated protein 6;Daxx;ETS1-associated protein 1;Fas death domain-associated protein |
| Gene name | DAXX;BING2;DAP6 |
| Species | Homo sapiens |
| Localization | Cytoplasm; Nucleus, nucleoplasm; Nucleus, PML body; Nucleus, nucleolus; Chromosome, centromere. |
| Description | Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. DAXX contains a DAXX helical bundle (DHB) domain, a helical region, and a C-terminal disordered domain. DAXX contains at least 8 predicted SPOP-binding motifs in its IDRs, making it a likely candidate to regulate SPOP localization. |
| GO term | GO:0050681; androgen receptor binding; IPI:UniProtKB. GO:0019899; enzyme binding; IPI:UniProtKB. GO:0031072; heat shock protein binding; TAS:UniProtKB. GO:0042393; histone binding; IDA:UniProtKB. GO:0002039; p53 binding; IPI:UniProtKB. GO:0042803; protein homodimerization activity; IDA:UniProtKB. GO:0030295; protein kinase activator activity; IGI:ParkinsonsUK-UCL. GO:0019901; protein kinase binding; IPI:ParkinsonsUK-UCL. GO:0047485; protein N-terminus binding; IPI:UniProtKB. GO:0140037; sumo-dependent protein binding; IPI:UniProtKB. GO:0003713; transcription coactivator activity; IDA:UniProtKB. GO:0003714; transcription corepressor activity; IDA:UniProtKB. GO:0008134; transcription factor binding; IDA:UniProtKB. GO:0140416; transcription regulator inhibitor activity; IDA:GO_Central. GO:0031625; ubiquitin protein ligase binding; IPI:UniProtKB. |
| Full sequence length | 740 |
| Database linked | MobiDB :Q9UER7 DisProt :DP00707 IDEAL :IID00398 OMIM :603186 |
| IDR Region | 1 740 |
| LCR Region | 1 740 |