| Full protein name | Amyloid-beta precursor protein;ABPP;APPI;Alzheimer disease amyloid protein;Amyloid precursor protein;Amyloid-beta A4 protein;Cerebral vascular amyloid peptide;PreA4;Protease nexin-II |
| Gene name | APP;A4;AD1 |
| Species | Homo sapiens |
| Localization | Cell membrane; Single- pass type I membrane protein; Membrane; Single- pass type I membrane protein; Perikaryon; Cell projection, growth cone; Membrane, clathrin-coated pit; Early endosome; Cytoplasmic vesicle. |
| Description | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. |
| GO term | GO:0030549; acetylcholine receptor activator activity; TAS:ARUK-UCL. GO:0033130; acetylcholine receptor binding; IPI:UniProtKB. GO:0097645; amylin binding; TAS:ARUK-UCL. GO:0034185; apolipoprotein binding; IPI:ARUK-UCL. GO:0051087; chaperone binding; IPI:ARUK-UCL. GO:0042056; chemoattractant activity; IGI:ARUK-UCL. GO:0003682; chromatin binding; IGI:ARUK-UCL. GO:0003677; DNA binding; ISS:UniProtKB. GO:0019899; enzyme binding; IPI:ARUK-UCL. GO:0046875; ephrin receptor binding; IPI:ARUK-UCL. GO:0005109; frizzled binding; IPI:ARUK-UCL. GO:0001664; G protein-coupled receptor binding; IPI:ARUK-UCL. GO:0070851; growth factor receptor binding; IEA:Ensembl. GO:1904399; heparan sulfate binding; TAS:ARUK-UCL. GO:0043395; heparan sulfate proteoglycan binding; IMP:ARUK-UCL. GO:0008201; heparin binding; IEA:UniProtKB-KW. GO:0042802; identical protein binding; IPI:IntAct. GO:0005158; insulin receptor binding; IPI:ARUK-UCL. GO:0005178; integrin binding; IDA:ARUK-UCL. GO:0050750; low-density lipoprotein particle receptor binding; ISS:ARUK-UCL. GO:0016504; peptidase activator activity; IEA:Ensembl. GO:0046983; protein dimerization activity; IDA:ARUK-UCL. GO:0046982; protein heterodimerization activity; IPI:ARUK-UCL. GO:0042803; protein homodimerization activity; IDA:ARUK-UCL. GO:0051425; PTB domain binding; IPI:BHF-UCL. GO:0050786; RAGE receptor binding; IPI:ARUK-UCL. GO:0000978; RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl. GO:0004867; serine-type endopeptidase inhibitor activity; IDA:UniProtKB. GO:0030546; signaling receptor activator activity; IDA:ARUK-UCL. GO:0005102; signaling receptor binding; IPI:ARUK-UCL. GO:0046914; transition metal ion binding; IEA:InterPro. |
| Full sequence length | 770 |
| Database linked | MobiDB :P05067 DisProt :DP01280 AmyPro :AP00010 AP00011 FuzDB :FC00365 IDEAL :IID00294 OMIM :104760 |
| IDR Region | 1 770 |
| LCR Region | 1 770 |