Full protein name | Cellular tumor antigen p53;Antigen NY-CO-13;Phosphoprotein p53;Tumor suppressor p53 |
Gene name | TP53;P53 |
Species | Homo sapiens |
Localization | Nucleus; Cytoplasm. |
Description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seems to have an effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 |
GO term | GO:0036310; annealing helicase activity; IDA:UniProtKB. GO:0051087; chaperone binding; IPI:UniProtKB. GO:0003682; chromatin binding; IDA:UniProtKB. GO:0000987; cis-regulatory region sequence-specific DNA binding; IDA:ARUK-UCL. GO:0005507; copper ion binding; IDA:UniProtKB. GO:0001046; core promoter sequence-specific DNA binding; IDA:CAFA. GO:0097718; disordered domain specific binding; IPI:CAFA. GO:0003677; DNA binding; IDA:UniProtKB. GO:0001216; DNA-binding transcription activator activity; IDA:ARUK-UCL. GO:0001228; DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:GO_Central. GO:0003700; DNA-binding transcription factor activity; IDA:UniProtKB. GO:0000981; DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:UniProtKB. GO:0019899; enzyme binding; IPI:UniProtKB. GO:0140296; general transcription initiation factor binding; IPI:BHF-UCL. GO:0035035; histone acetyltransferase binding; IPI:UniProtKB. GO:0042826; histone deacetylase binding; IPI:CAFA. GO:0035033; histone deacetylase regulator activity; IEA:Ensembl. GO:0042802; identical protein binding; IPI:UniProtKB. GO:0097371; MDM2/MDM4 family protein binding; IEA:Ensembl. GO:0003730; mRNA 3'-UTR binding; IDA:CAFA. GO:0002039; p53 binding; IPI:CAFA. GO:1990841; promoter-specific chromatin binding; IDA:UniProtKB. GO:0002020; protease binding; IPI:UniProtKB. GO:0046982; protein heterodimerization activity; IPI:UniProtKB. GO:0019901; protein kinase binding; IPI:UniProtKB. GO:0047485; protein N-terminus binding; IPI:UniProtKB. GO:0051721; protein phosphatase 2A binding; IPI:UniProtKB. GO:0019903; protein phosphatase binding; IPI:UniProtKB. GO:0043621; protein self-association; IPI:AgBase. GO:0030971; receptor tyrosine kinase binding; IPI:BHF-UCL. GO:0000978; RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL. GO:0061629; RNA polymerase II-specific DNA-binding transcription factor binding; IPI:BHF-UCL. GO:0001094; TFIID-class transcription factor complex binding; IPI:ParkinsonsUK-UCL. GO:0000976; transcription cis-regulatory region binding; IDA:BHF-UCL. GO:0008134; transcription factor binding; IPI:UniProtKB. GO:0031625; ubiquitin protein ligase binding; IPI:UniProtKB. GO:0008270; zinc ion binding; TAS:UniProtKB. |
Full sequence length | 393 |
Database linked | MobiDB :P04637  DisProt :DP00086  AmyPro :AP00093  FuzDB :FC00084  IDEAL :IID00015  OMIM :191170   |
IDR Region | 1 393      |
LCR Region | 1 393      |