| Full protein name | Transcription factor SOX-2 |
| Gene name | SOX2 |
| Species | Homo sapiens |
| Localization | Nucleus. |
| Description | Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. |
| GO term | GO:0003677; DNA binding; IDA:UniProtKB. GO:0001228; DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl. GO:0003700; DNA-binding transcription factor activity; IDA:UniProtKB. GO:0000981; DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. GO:0035198; miRNA binding; IDA:UniProtKB. GO:0000978; RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. GO:0043565; sequence-specific DNA binding; IDA:MGI. GO:0000976; transcription cis-regulatory region binding; IDA:UniProtKB. |
| Full sequence length | 317 |
| Database linked | MobiDB :P48431 IDEAL :IID00626 OMIM :184429 |
| IDR Region | 1 317 |
| LCR Region | 1 317 |