| Full protein name | Retinoic acid receptor alpha;Nuclear receptor subfamily 1 group B member 1 |
| Gene name | RARA;NR1B1 |
| Species | Homo sapiens |
| Localization | Nucleus; Cytoplasm. |
| Description | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. |
| GO term | GO:0051393; alpha-actinin binding; IPI:UniProtKB. GO:0003682; chromatin binding; IDA:UniProtKB. GO:0031490; chromatin DNA binding; IDA:UniProtKB. GO:0003700; DNA-binding transcription factor activity; IDA:UniProtKB. GO:0000981; DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. GO:0019899; enzyme binding; IPI:UniProtKB. GO:0042826; histone deacetylase binding; IEA:Ensembl. GO:0048027; mRNA 5'-UTR binding; IEA:Ensembl. GO:0004879; nuclear receptor activity; IDA:ARUK-UCL. GO:0019904; protein domain specific binding; IPI:UniProtKB. GO:0051018; protein kinase A binding; IDA:UniProtKB. GO:0043422; protein kinase B binding; IPI:UniProtKB. GO:0001972; retinoic acid binding; IDA:BHF-UCL. GO:0044323; retinoic acid-responsive element binding; IDA:UniProtKB. GO:0000978; RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB. GO:0000977; RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:UniProtKB. GO:1990837; sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. GO:0005102; signaling receptor binding; IDA:UniProtKB. GO:0008134; transcription factor binding; IPI:UniProtKB. GO:0000900; translation repressor activity, mRNA regulatory element binding; IEA:Ensembl. GO:0008270; zinc ion binding; IEA:InterPro. |
| Full sequence length | 462 |
| Database linked | MobiDB :P10276 IDEAL :IID00365 OMIM :180240 |
| IDR Region | 1 462 |
| LCR Region | 1 462 |