| Full protein name | Estrogen receptor;ER-alpha;Estradiol receptor;Nuclear receptor subfamily 3 group A member 1 |
| Gene name | ESR1;ESR;NR3A1 |
| Species | Homo sapiens |
| Localization | Nucleus; Cytoplasm; Cell membrane; Peripheral membrane protein; Cytoplasmic side. |
| Description | Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. ER is a well-studied example of a ligand-dependent transcription factor. ER consists of an N-terminal ligand-independent activation domain, a central DNA binding domain, and a C-terminal ligand-dependent activation domain. |
| GO term | GO:0051117; ATPase binding; IDA:MGI. GO:0008013; beta-catenin binding; IPI:BHF-UCL. GO:0003682; chromatin binding; IDA:UniProtKB. GO:0001228; DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB. GO:0003700; DNA-binding transcription factor activity; NAS:BHF-UCL. GO:0000981; DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB. GO:0019899; enzyme binding; IPI:UniProtKB. GO:0030284; estrogen receptor activity; IDA:BHF-UCL. GO:0030331; estrogen receptor binding; IPI:CAFA. GO:0034056; estrogen response element binding; IDA:UniProtKB. GO:0042802; identical protein binding; IPI:IntAct. GO:0030235; nitric-oxide synthase regulator activity; NAS:UniProtKB. GO:0004879; nuclear receptor activity; IDA:BHF-UCL. GO:0019901; protein kinase binding; IPI:UniProtKB. GO:0000978; RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB. GO:1990837; sequence-specific double-stranded DNA binding; IDA:ARUK-UCL. GO:0005496; steroid binding; ISS:UniProtKB. GO:0017025; TBP-class protein binding; IPI:CAFA. GO:0001093; TFIIB-class transcription factor binding; IPI:CAFA. GO:0001223; transcription coactivator binding; IPI:UniProtKB. GO:0001222; transcription corepressor binding; IPI:ARUK-UCL. GO:0008134; transcription factor binding; IPI:UniProtKB. GO:0008270; zinc ion binding; IEA:InterPro. |
| Full sequence length | 595 |
| Database linked | MobiDB :P03372 DisProt :DP00074 IDEAL :IID00013 OMIM :133430 |
| IDR Region | 1 595 |
| LCR Region | 1 595 |