| Full protein name | DNA topoisomerase 2-associated protein PAT1;mRNA turnover protein 1 |
| Gene name | PAT1 |
| Species | Saccharomyces cerevisiae |
| Localization | N/A |
| Description | Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. First decay factor recruited to mRNA, at a time when the mRNA is still associated with translation factors. Subsequently, PAT1 recruits the hepta-heterodimer LSM1-LSM7 complex to P-bodies. In association with the LSM1-LSM7 complex, stabilizes the 3' terminus of mRNAs. This association is also required for mosaic virus genomic RNA translation. Modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Required for 40S ribosomal subunit joining to capped and/or polyadenylated mRNA. With other P-body components, enhances the formation of retrotransposition-competent Ty1 virus-like particles. Necessary for accurate chromosome transmission during cell division. |
| GO term | GO:0003682; chromatin binding; IDA:SGD. GO:0003729; mRNA binding; IDA:SGD. GO:0003723; RNA binding; IDA:SGD. |
| Full sequence length | 796 |
| Database linked | MobiDB :P25644 DisProt :DP01825 |
| IDR Region | 1 796 |
| LCR Region | 1 796 |