| Full protein name | ATP-dependent RNA helicase DDX3X |
| Gene name | DDX3X |
| Species | Homo sapiens |
| Localization | Cytoplasm; Membrane; Mitochondrion; Mitochondrion outer membrane; Nucleus. |
| Description | Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo- and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Is involved in several steps of gene expression, such as transcription, mRNA maturation, mRNA export and translation. Proposed to be involved in stress response and stress granule assembly; the function is independent of RNA helicase activity and seems to involve association with EIF4E. May be involved in nuclear export of specific mRNAs but not in bulk mRNA export via interactions with XPO1 and NXF1. Also associates with polyadenylated mRNAs independently of NXF1. Associates with spliced mRNAs in an exon junction complex (EJC)-dependent manner and seems not to be directly involved in splicing. Involved in innate immune signaling promoting the production of type I interferon (IFN-alpha and IFN-beta). Involved in regulation of apoptosis. May be required for activation of the intrinsic but inhibit activation of the extrinsic apoptotic pathway. DDX3X harbors two IDRs, one at the N terminus, where K118 is localized, and one at the C terminus. |
| GO term | GO:0005524; ATP binding; IEA:UniProtKB-KW. GO:0140603; ATP hydrolysis activity; IDA:UniProtKB. GO:0016887; ATPase; IDA:AgBase. GO:0045296; cadherin binding; HDA:BHF-UCL. GO:0043273; CTPase activity; IDA:AgBase. GO:0003677; DNA binding; IDA:UniProtKB. GO:0003678; DNA helicase activity; IDA:UniProtKB. GO:0008190; eukaryotic initiation factor 4E binding; IDA:UniProtKB. GO:0043015; gamma-tubulin binding; IDA:UniProtKB. GO:0003924; GTPase activity; IDA:AgBase. GO:0048027; mRNA 5'-UTR binding; IDA:UniProtKB. GO:0003729; mRNA binding; IDA:UniProtKB. GO:0017111; nucleoside-triphosphatase activity; IDA:AgBase. GO:0008143; poly(A) binding; IDA:UniProtKB. GO:0043539; protein serine/threonine kinase activator activity; IDA:UniProtKB. GO:0043024; ribosomal small subunit binding; IDA:UniProtKB. GO:0003723; RNA binding; IDA:UniProtKB. GO:0003724; RNA helicase activity; IDA:UniProtKB. GO:0035613; RNA stem-loop binding; IDA:UniProtKB. GO:0033592; RNA strand annealing activity; IDA:UniProtKB. GO:0008134; transcription factor binding; IDA:UniProtKB. GO:0031369; translation initiation factor binding; IDA:UniProtKB. |
| Full sequence length | 662 |
| Database linked | MobiDB :O00571 DisProt :DP02192 IDEAL :IID00232 OMIM :300106 |
| IDR Region | 1 662 |
| LCR Region | 1 662 |