| Full protein name | Eukaryotic translation initiation factor 4E-binding protein 2;4E-BP2;eIF4E-binding protein 2;EIF4EBP2 |
| Gene name | EIF4EBP2 |
| Species | Homo sapiens |
| Localization | Cytoplasm.Postsynapse. |
| Description | Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| GO term | GO:0008190; eukaryotic initiation factor 4E binding; ISS:UniProtKB. GO:0030371; translation repressor activity; ISS:UniProtKB. |
| Full sequence length | 120 |
| Database linked | MobiDB :Q13542 DisProt :DP01293 FuzDB :FC00072 IDEAL :IID00564 OMIM :602224 |
| IDR Region | 1 120 |
| LCR Region | 1 120 |