| Full protein name | Importin subunit alpha-1;Karyopherin subunit alpha-2;RAG cohort protein 1;SRP1-alpha |
| Gene name | KPNA2;RCH1;SRP1 |
| Species | Homo sapiens |
| Localization | Cytoplasm;Nucleus. |
| Description | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. |
| GO term | GO:0042826; histone deacetylase binding; IPI:BHF-UCL. GO:0061608; nuclear import signal receptor activity; IBA:GO_Central. GO:0008139; nuclear localization sequence binding; IDA:UniProtKB. GO:0003723; RNA binding; HDA:UniProtKB. |
| Full sequence length | 529 |
| Database linked | MobiDB :P52292 DisProt :DP01687 IDEAL :IID00153 OMIM :600685 |
| IDR Region | 1 529 |
| LCR Region | 1 529 |