| Full protein name | Exportin-1;Exp1;Chromosome region maintenance 1 protein homolog |
| Gene name | XPO1;CRM1 |
| Species | Homo sapiens |
| Localization | Cytoplasm;Nucleus,nucleoplasm;Nucleus,Cajal body;Nucleus,nucleolus. |
| Description | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. |
| GO term | GO:0005049; nuclear export signal receptor activity; IDA:UniProtKB. GO:0019904; protein domain specific binding; IEA:Ensembl. GO:0003723; RNA binding; IEA:UniProtKB-KW. GO:0031267; small GTPase binding; IEA:InterPro. |
| Full sequence length | 1071 |
| Database linked | MobiDB :O14980 DisProt :DP01916 IDEAL :IID00357 OMIM :602559 |
| IDR Region | 1 1071 |
| LCR Region | 1 1071 |