| Full protein name | Eukaryotic translation initiation factor 4E;eIF-4E;eIF4E;eIF-4F 25 kDa subunit;mRNA cap-binding protein;eIF-4F 25 kDa subunit;mRNA cap-binding protein |
| Gene name | EIF4E |
| Species | Homo sapiens |
| Localization | P-body;Cytoplasm.Cytoplasm.Cytoplasm,Stress granule.Nucleus. |
| Description | Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. |
| GO term | GO:0140297; DNA-binding transcription factor binding; IDA:AgBase. GO:0019899; enzyme binding; IDA:AgBase. GO:0031370; eukaryotic initiation factor 4G binding; IDA:AgBase. GO:0000340; RNA 7-methylguanosine cap binding; IDA:UniProtKB. GO:0003723; RNA binding; HDA:UniProtKB. GO:0000339; RNA cap binding; TAS:ProtInc. GO:0003743; translation initiation factor activity; IDA:UniProtKB. |
| Full sequence length | 217 |
| Database linked | MobiDB :P06730 DisProt :DP02399 IDEAL :IID00341 OMIM :133440 |
| IDR Region | 1 217 |
| LCR Region | 1 217 |