| Full protein name | CCR4-NOT transcription complex subunit 7 |
| Gene name | CNOT7 |
| Species | Homo sapiens |
| Localization | Nucleus;P-body |
| Description | Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. |
| GO term | GO:0000175; 3'-5'-exoribonuclease activity; IDA:UniProtKB. GO:0004532; exoribonuclease activity; IDA:UniProtKB. GO:0046872; metal ion binding; IEA:UniProtKB-KW. GO:0004535; poly(A)-specific ribonuclease activity; IDA:UniProtKB. GO:0003723; RNA binding; IEA:UniProtKB-KW. GO:0003714; transcription corepressor activity; IMP:UniProtKB. GO:0008134; transcription factor binding; IPI:UniProtKB. |
| Full sequence length | 285 |
| Database linked | MobiDB :Q9UIV1 IDEAL :IID00504 OMIM :604913 |
| IDR Region | 1 285 |
| LCR Region | 1 285 |