| Full protein name | U1 small nuclear ribonucleoprotein 70 kDa;U1 snRNP 70 kDa;U1-70K;snRNP70 |
| Gene name | SNRNP70;RNPU1Z;RPU1;SNRP70;U1AP1 |
| Species | Homo sapiens |
| Localization | Nucleus speckle; Nucleus, nucleoplasm. |
| Description | U1-70K is an RNA binding protein and a component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-70K may aggregates and associates exclusively with tau in the cortex of AD patients. |
| GO term | GO:0003729; mRNA binding; IBA:GO_Central. GO:0003723; RNA binding; IMP:UniProtKB. GO:0017069; snRNA binding; IBA:GO_Central. GO:0030619; U1 snRNA binding; IDA:UniProtKB. |
| Full sequence length | 437 |
| Database linked | MobiDB :P08621 DisProt :DP02171 IDEAL :IID00138 OMIM :180740 |
| IDR Region | 1 437 |
| LCR Region | 1 437 |