| Full protein name | Alpha-synuclein;Non-A beta component of AD amyloid;Non-A4 component of amyloid precursor;NACP |
| Gene name | SNCA;NACP, PARK1 |
| Species | Homo sapiens |
| Localization | Cytoplasm.Membrane.Nucleus.Cell junction,synapse.Secreted. |
| Description | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590). |
| GO term | GO:0003779; actin binding; IPI:ARUK-UCL. GO:0043014; alpha-tubulin binding; IPI:UniProtKB. GO:0048487; beta-tubulin binding; IEA:Ensembl. GO:0005509; calcium ion binding; IDA:UniProtKB. GO:0005507; copper ion binding; IDA:UniProtKB. GO:1903136; cuprous ion binding; IMP:CAFA. GO:0043027; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB. GO:0070840; dynein complex binding; IPI:UniProtKB. GO:0008198; ferrous iron binding; IDA:UniProtKB. GO:0042393; histone binding; IDA:UniProtKB. GO:0030544; Hsp70 protein binding; IPI:UniProtKB. GO:0042802; identical protein binding; IDA:UniProtKB. GO:0019894; kinesin binding; IPI:UniProtKB. GO:0000287; magnesium ion binding; IDA:UniProtKB. GO:0008017; microtubule binding; IEA:Ensembl. GO:0016491; oxidoreductase activity; IDA:UniProtKB. GO:0043274; phospholipase binding; IEA:Ensembl. GO:0005543; phospholipid binding; IDA:ParkinsonsUK-UCL. GO:0051219; phosphoprotein binding; IDA:BHF-UCL. GO:0019904; protein domain specific binding; IEA:Ensembl. GO:0004860; protein kinase inhibitor activity; TAS:ARUK-UCL. GO:0047485; protein N-terminus binding; IEA:Ensembl. GO:0000149; SNARE binding; IDA:UniProtKB. GO:0048156; tau protein binding; IDA:UniProtKB. GO:0000976; transcription cis-regulatory region binding; TAS:ParkinsonsUK-UCL. GO:0008270; zinc ion binding; IDA:UniProtKB. |
| Full sequence length | 140 |
| Database linked | MobiDB :P37840 DisProt :DP00070 AmyPro :AP00015 FuzDB :FC00080 OMIM :163890 |
| IDR Region | 1 140 |
| LCR Region | 1 140 |