| Full protein name | Splicing factor U2AF 65 kDa subunit;U2 auxiliary factor 65 kDa subunit;hU2AF(65);hU2AF65;U2 snRNP auxiliary factor large subunit |
| Gene name | U2af2;U2af65 |
| Species | Homo sapiens |
| Localization | Nucleus. |
| Description | Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals. |
| GO term | GO:0070742; C2H2 zinc finger domain binding; IEA:Ensembl. GO:0019899; enzyme binding; IPI:UniProtKB. GO:0008187; poly-pyrimidine tract binding; IBA:GO_Central. GO:0030628; pre-mRNA 3'-splice site binding; IDA:GO_Central. GO:0003723; RNA binding; HDA:UniProtKB. |
| Full sequence length | 475 |
| Database linked | MobiDB :P26368 DisProt :DP02921 FuzDB :FC00148 OMIM :191318 |
| IDR Region | 1 475 |
| LCR Region | 1 475 |