53BP1 Q12888

Full protein name TP53-binding protein 1;53BP1;p53-binding protein 1;p53BP1
Gene name TP53BP1
Species Homo sapiens
Localization Nucleus;Chromosome;Chromosome,centromere,kinetochore.
Description 53BP1 generates sizeable chromatin domains, which scaffold the assembly of downstream effectors and shield DNA lesions against excessive nucleolytic digestion. Restrained resection is achieved by 53BP1-dependent recruitment of RIF1, REV7, and the Shieldin complex. Additionally, 53BP1 promotes cell cycle checkpoint signaling in response to DNA damage.
GO term GO:0003684; damaged DNA binding; IEA:Ensembl.
GO:0042393; histone binding; IBA:GO_Central.
GO:0035064; methylated histone binding; IDA:UniProtKB.
GO:0002039; p53 binding; IPI:AgBase.
GO:0061629; RNA polymerase II-specific DNA-binding transcription factor binding; IPI:BHF-UCL.
GO:0042162; telomeric DNA binding; IEA:Ensembl.
GO:0003712; transcription coregulator activity; IMP:BHF-UCL.
GO:0061649; ubiquitin modification-dependent histone binding; IDA:UniProtKB.
Full sequence length 1972
Database linked MobiDB :Q12888  DisProt :DP02954  OMIM :605230  
IDR Region1 1459-1484 1603-1634 1741-1770 1972     
LCR Region1 132-148 413-425 583-596 652-669 1263-1275 1293-1307 1316-1335 1392-1412 1634-1650 1758-1764 1972