| Full protein name | Ras GTPase-activating protein-binding protein 1;ATP-dependent DNA helicase VIII;GAP SH3 domain-binding protein 1 |
| Gene name | G3BP1;G3BP |
| Species | Homo sapiens |
| Localization | Cytoplasm, cytosol. Perikaryon. Cytoplasm, Stress granule. Nucleus. |
| Description | ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. |
| GO term | GO:0005524; ATP binding; IEA:UniProtKB-KW. GO:0140603; ATP hydrolysis activity; IEA:RHEA. GO:0003677; DNA binding; IEA:UniProtKB-KW. GO:0003678; DNA helicase activity; IDA:FlyBase. GO:0033677; DNA/RNA helicase activity; IDA:FlyBase. GO:0004519; endonuclease activity; IEA:UniProtKB-KW. GO:0003729; mRNA binding; IBA:GO_Central. GO:0003723; RNA binding; HDA:UniProtKB. GO:0003724; RNA helicase activity; IDA:FlyBase. |
| Full sequence length | 466 |
| Database linked | MobiDB :Q13283 OMIM :608431 |
| IDR Region | 1 466 |
| LCR Region | 1 466 |