| Full protein name | Heterogeneous nuclear ribonucleoprotein A1;Helix-destabilizing protein;Single-strand RNA-binding protein;hnRNP core protein A1 |
| Gene name | HNRNPA1;HNRPA1 |
| Species | Homo sapiens |
| Localization | Nucleus. Cytoplasm. Cytoplasm. |
| Description | Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. (Microbial infection) May play a role in HCV RNA replication. (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. |
| GO term | GO:0098505; G-rich strand telomeric DNA binding; IDA:BHF-UCL. GO:0042802; identical protein binding; IPI:IntAct. GO:0035198; miRNA binding; IDA:UniProtKB. GO:0036002; pre-mRNA binding; IDA:CAFA. GO:0019904; protein domain specific binding; IPI:UniProtKB. GO:0003723; RNA binding; HDA:UniProtKB. GO:0003697; single-stranded DNA binding; IDA:HGNC-UCL. GO:0003727; single-stranded RNA binding; IC:HGNC-UCL. GO:0061752; telomeric repeat-containing RNA binding; IDA:BHF-UCL. |
| Full sequence length | 372 |
| Database linked | MobiDB :P09651 DisProt :DP00324 IDEAL :IID00119 OMIM :164017 |
| IDR Region | 1 372 |
| LCR Region | 1 372 |