| Full protein name | Methyl-CpG-binding protein 2 |
| Gene name | MECP2 |
| Species | Homo sapiens |
| Localization | Nucleus. |
| Description | Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). |
| GO term | GO:0003682; chromatin binding; IBA:GO_Central. GO:0003677; DNA binding; IBA:GO_Central. GO:0003700; DNA-binding transcription factor activity; IEA:Ensembl. GO:0010385; double-stranded methylated DNA binding; IMP:MGI. GO:0008327; methyl-CpG binding; IBA:GO_Central. GO:0003729; mRNA binding; IEA:Ensembl. GO:1990841; promoter-specific chromatin binding; IEA:Ensembl. GO:0019904; protein domain specific binding; IPI:UniProtKB. GO:0047485; protein N-terminus binding; IPI:UniProtKB. GO:0003723; RNA binding; HDA:UniProtKB. GO:0035197; siRNA binding; IEA:Ensembl. GO:0003714; transcription corepressor activity; IDA:ARUK-UCL. |
| Full sequence length | 486 |
| Database linked | MobiDB :P51608 DisProt :DP00539 FuzDB :FC00043 OMIM :300005 |
| IDR Region | 1 486 |
| LCR Region | 1 486 |