| Full protein name | WW domain-containing transcription regulator protein 1;Transcriptional coactivator with PDZ-binding motif |
| Gene name | WWTR1;TAZ |
| Species | Homo sapiens |
| Localization | Nucleus. Cytoplasm. Cell membrane. |
| Description | Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. |
| GO term | GO:0042803; protein homodimerization activity; IEA:Ensembl. GO:0003713; transcription coactivator activity; IDA:UniProtKB. GO:0003714; transcription corepressor activity; IBA:GO_Central. |
| Full sequence length | 400 |
| Database linked | MobiDB :Q9GZV5 OMIM :607392 |
| IDR Region | 1 400 |
| LCR Region | 1 400 |