| Full protein name | B-cell linker protein;B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;Cytoplasmic adapter protein;Src homology 2 domain-containing leukocyte protein of 65 kDa |
| Gene name | BLNK;BASH, SLP65 |
| Species | Homo sapiens |
| Localization | Cytoplasm. Cell membrane. |
| Description | Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. |
| GO term | GO:0019899; enzyme binding; IPI:UniProtKB. GO:0043274; phospholipase binding; IPI:ARUK-UCL. GO:0019901; protein kinase binding; IPI:ARUK-UCL. GO:1990782; protein tyrosine kinase binding; IPI:UniProtKB. GO:0042169; SH2 domain binding; IDA:UniProtKB. GO:0035591; signaling adaptor activity; IDA:UniProtKB. GO:0005068; transmembrane receptor protein tyrosine kinase adaptor activity; TAS:ProtInc. |
| Full sequence length | 456 |
| Database linked | MobiDB :Q8WV28 DisProt :DP01544 OMIM :604515 |
| IDR Region | 1 456 |
| LCR Region | 1 456 |