| Full protein name | Galectin-3;35 kDa lectin;Carbohydrate-binding protein 35;Galactose-specific lectin 3;Galactoside-binding protein;IgE-binding protein;L-31;Laminin-binding protein;Lectin L-29;Mac-2 antigen |
| Gene name | LGALS3 ;MAC2 |
| Species | Homo sapiens |
| Localization | Cytoplasm. Nucleus. Secreted. |
| Description | Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. |
| GO term | GO:0030246; carbohydrate binding; TAS:ProtInc. GO:0042056; chemoattractant activity; IDA:BHF-UCL. GO:0019863; IgE binding; IDA:BHF-UCL. GO:0043236; laminin binding; IDA:BHF-UCL. GO:0070492; oligosaccharide binding; IDA:UniProtKB. GO:0019903; protein phosphatase binding; IPI:ARUK-UCL. GO:0004864; protein phosphatase inhibitor activity; IC:ARUK-UCL. GO:0003723; RNA binding; HDA:UniProtKB. |
| Full sequence length | 250 |
| Database linked | MobiDB :P17931 DisProt :DP01332 IDEAL :IID00029 OMIM :153619 |
| IDR Region | 1 250 |
| LCR Region | 1 250 |