MLL4 O14686

Full protein name Histone-lysine N-methyltransferase 2D;ALL1-related protein;Myeloid/lymphoid or mixed-lineage leukemia protein 2
Gene name KMT2D;ALR, MLL2, MLL4
Species Homo sapiens
Localization Nucleus.
Description Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.
GO term GO:0003677; DNA binding; NAS:UniProtKB.
GO:0042393; histone binding; IBA:GO_Central.
GO:0042800; histone methyltransferase activity (H3-K4 specific); IBA:GO_Central.
GO:0046872; metal ion binding; IEA:UniProtKB-KW.
GO:0000976; transcription cis-regulatory region binding; IDA:UniProtKB.
GO:0003713; transcription coactivator activity; IBA:GO_Central.
Full sequence length 5537
Database linked MobiDB :O14686  DisProt :DP01676  IDEAL :IID00356  OMIM :602113  
IDR Region1 0-0 5537     
LCR Region1 95-105 134-148 374-386 430-483 488-736 842-871 875-954 993-1014 1034-1057 1104-1111 1281-1292 1303-1328 1351-1358 1558-1574 1611-1620 1633-1656 1678-1690 1751-1763 1974-1993 2107-2122 2190-2210 2349-2366 2377-2401 2409-2431 2445-2462 2489-2506 2545-2559 2589-2604 2607-2624 2676-2697 2707-2722 2767-2778 2810-2822 2862-2874 2887-2906 2930-2940 3085-3102 3198-3210 3252-3289 3301-3320 3367-3379 3578-3614 3631-3657 3676-3702 3715-3759 3783-3806 3855-3868 3872-3886 3896-3975 3988-3994 4012-4023 4073-4108 4112-4129 4209-4236 4252-4275 4277-4296 4300-4331 4548-4564 4610-4633 4694-4704 4826-4848 4906-4970 5049-5056 5494-5502 5537