| Full protein name | Probable ATP-dependent RNA helicase DDX6;ATP-dependent RNA helicase p54;DEAD box protein 6;Oncogene RCK |
| Gene name | DDX6;HLR2;RCK |
| Species | Homo sapiens |
| Localization | Cytoplasm, P-body.Cytoplasm.Nucleus. |
| Description | Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions (PubMed:25995375, PubMed:27342281, PubMed:31422817).Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:27342281).In the process of mRNA degradation, plays a role in mRNA decapping (PubMed:16364915).Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts (PubMed:26098573). |
| GO term | GO:0005524; ATP binding; IEA:UniProtKB-KW. GO:0140603; ATP hydrolysis activity; IEA:RHEA. GO:0045296; cadherin binding; HDA:BHF-UCL. GO:0004386; helicase activity; TAS:ProtInc. GO:0003729; mRNA binding; IBA:GO_Central. GO:0019904; protein domain specific binding; IPI:BHF-UCL. GO:0003723; RNA binding; HDA:UniProtKB. GO:0003724; RNA helicase activity; TAS:ProtInc. |
| Full sequence length | 483 |
| Database linked | MobiDB :P26196 OMIM :600326 |
| IDR Region | 1 483 |
| LCR Region | 1 483 |