| Full protein name | Nuclear receptor coactivator 3;ACTR;Amplified in breast cancer 1 protein;CBP-interacting protein;Class E basic helix-loop-helix protein 42;Receptor-associated coactivator 3;Steroid receptor coactivator protein 3;Thyroid hormone receptor activator molecule 1 |
| Gene name | NCOA3;AIB1, BHLHE42, RAC3, TRAM1; |
| Species | Homo sapiens |
| Localization | Cytoplasm. Nucleus. |
| Description | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. |
| GO term | GO:0097718; disordered domain specific binding; IPI:CAFA. GO:0004402; histone acetyltransferase activity; IDA:UniProtKB. GO:0016922; nuclear receptor binding; IDA:UniProtKB. GO:0030374; nuclear receptor coactivator activity; IBA:GO_Central. GO:0046983; protein dimerization activity; IEA:InterPro. GO:0047485; protein N-terminus binding; IPI:UniProtKB. GO:0000993; RNA polymerase II complex binding; ISS:UniProtKB. GO:0046966; thyroid hormone receptor binding; NAS:UniProtKB. GO:0003713; transcription coactivator activity; IDA:UniProtKB. |
| Full sequence length | 1424 |
| Database linked | MobiDB :Q9Y6Q9 DisProt :DP00343 IDEAL :IID00110 OMIM :601937 |
| IDR Region | 1 1424 |
| LCR Region | 1 1424 |